Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China
Identifieur interne : 000666 ( Main/Exploration ); précédent : 000665; suivant : 000667Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China
Auteurs : Wenling Wang [République populaire de Chine] ; Huijuan Wang [République populaire de Chine] ; Yao Deng [République populaire de Chine] ; Tie Song [République populaire de Chine] ; Jiaming Lan [République populaire de Chine] ; Guizhen Wu [République populaire de Chine] ; Changwen Ke [République populaire de Chine] ; Wenjie Tan [République populaire de Chine]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2019.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Anticorps neutralisants (sang), Antigènes viraux (immunologie), Chine, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunoglobuline G (sang), Immunoglobuline M (sang), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Mâle, Nucléoprotéines (immunologie), Protéines recombinantes (immunologie), Test ELISA, Tests de neutralisation.
- MESH :
- immunologie : Anticorps antiviraux, Antigènes viraux, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Nucléoprotéines, Protéines recombinantes.
- sang : Anticorps antiviraux, Anticorps neutralisants, Immunoglobuline G, Immunoglobuline M.
- virologie : Infections à coronavirus.
- Chine, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Mâle, Test ELISA, Tests de neutralisation.
English descriptors
- KwdEn :
- Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antibodies, Viral (immunology), Antigens, Viral (immunology), China, Coronavirus Infections (immunology), Coronavirus Infections (virology), Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin G (blood), Immunoglobulin M (blood), Male, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (immunology), Neutralization Tests, Nucleoproteins (immunology), Recombinant Proteins (immunology), Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- chemical , immunology : Antibodies, Viral, Antigens, Viral, Nucleoproteins, Recombinant Proteins, Spike Glycoprotein, Coronavirus.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- China, Enzyme-Linked Immunosorbent Assay, Humans, Male, Neutralization Tests.
Abstract
The first imported case of Middle East respiratory syndrome (MERS) in China recently
occurred, allowing for the characterization of antibody titers in a series of the
patient’s sera using the following methods based on recombinant viral structural antigens:
inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunosorbent assay (ELISA),
recombinant MERS-CoV spike (S, or fragments of S) ELISA, nucleoprotein (NP) ELISA and MERS
S pseudovirus particle-based neutralization test (ppNT). A longitudinal profile of the
infection showed that seroconversion detected by ELISAs based on the recombinant
extracellular domain, S, S1 and receptor-binding domain (RBD) antigens occurred as early
as neutralizing antibodies were detected by the ppNT and earlier than antibodies were
detected by the inactivated MERS-CoV and N-terminal domain (NTD) ELISAs. Antibodies
detected by the NP ELISA occurred last. Strong correlations were found between the S1, RBD
and NP ELISAs and the inactivated MERS-CoV ELISA. The S and RBD ELISAs were highly
correlated with the commercial S1 ELISA. The S ELISA strongly correlated with the ppNT,
although the MERS-CoV, S1, NTD and RBD ELISAs were also significantly correlated with the
ppNT (
Url:
DOI: 10.1038/emi.2016.114
PubMed: 27826140
PubMed Central: 5148018
Affiliations:
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Le document en format XML
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structural antigens of MERS-CoV in an imported case in China</title><author><name sortKey="Wang, Wenling" sort="Wang, Wenling" uniqKey="Wang W" first="Wenling" last="Wang">Wenling Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Huijuan" sort="Wang, Huijuan" uniqKey="Wang H" first="Huijuan" last="Wang">Huijuan Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Yao" sort="Deng, Yao" uniqKey="Deng Y" first="Yao" last="Deng">Yao Deng</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Song, Tie" sort="Song, Tie" uniqKey="Song T" first="Tie" last="Song">Tie Song</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Center for Disease Control and Prevention</institution>, Guangzhou 511430, Guangdong Province,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lan, Jiaming" sort="Lan, Jiaming" uniqKey="Lan J" first="Jiaming" last="Lan">Jiaming Lan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Guizhen" sort="Wu, Guizhen" uniqKey="Wu G" first="Guizhen" last="Wu">Guizhen Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Center for Disease Control and Prevention</institution>, Guangzhou 511430, Guangdong Province,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>Antigens, Viral (immunology)</term><term>China</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Neutralization Tests</term><term>Nucleoproteins (immunology)</term><term>Recombinant Proteins (immunology)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Antigènes viraux (immunologie)</term><term>Chine</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Immunoglobuline M (sang)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Mâle</term><term>Nucléoprotéines (immunologie)</term><term>Protéines recombinantes (immunologie)</term><term>Test ELISA</term><term>Tests de neutralisation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Antigens, Viral</term><term>Nucleoproteins</term><term>Recombinant Proteins</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Antigènes viraux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Infections à coronavirus</term><term>Nucléoprotéines</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>China</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Male</term><term>Neutralization Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Chine</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Mâle</term><term>Test ELISA</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The first imported case of Middle East respiratory syndrome (MERS) in China recently
occurred, allowing for the characterization of antibody titers in a series of the
patient’s sera using the following methods based on recombinant viral structural antigens:
inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunosorbent assay (ELISA),
recombinant MERS-CoV spike (S, or fragments of S) ELISA, nucleoprotein (NP) ELISA and MERS
S pseudovirus particle-based neutralization test (ppNT). A longitudinal profile of the
infection showed that seroconversion detected by ELISAs based on the recombinant
extracellular domain, S, S1 and receptor-binding domain (RBD) antigens occurred as early
as neutralizing antibodies were detected by the ppNT and earlier than antibodies were
detected by the inactivated MERS-CoV and N-terminal domain (NTD) ELISAs. Antibodies
detected by the NP ELISA occurred last. Strong correlations were found between the S1, RBD
and NP ELISAs and the inactivated MERS-CoV ELISA. The S and RBD ELISAs were highly
correlated with the commercial S1 ELISA. The S ELISA strongly correlated with the ppNT,
although the MERS-CoV, S1, NTD and RBD ELISAs were also significantly correlated with the
ppNT (<italic>P</italic><0.001).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Da X0a Guan, W" uniqKey="Da X0a Guan W">W Da
Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Sw" uniqKey="Park S">SW Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wernery, U" uniqKey="Wernery U">U Wernery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Wb" uniqKey="Park W">WB Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Yq" uniqKey="Wang Y">YQ Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Min, Ck" uniqKey="Min C">CK Min</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Wenling" sort="Wang, Wenling" uniqKey="Wang W" first="Wenling" last="Wang">Wenling Wang</name></noRegion><name sortKey="Deng, Yao" sort="Deng, Yao" uniqKey="Deng Y" first="Yao" last="Deng">Yao Deng</name><name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name><name sortKey="Lan, Jiaming" sort="Lan, Jiaming" uniqKey="Lan J" first="Jiaming" last="Lan">Jiaming Lan</name><name sortKey="Song, Tie" sort="Song, Tie" uniqKey="Song T" first="Tie" last="Song">Tie Song</name><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><name sortKey="Wang, Huijuan" sort="Wang, Huijuan" uniqKey="Wang H" first="Huijuan" last="Wang">Huijuan Wang</name><name sortKey="Wu, Guizhen" sort="Wu, Guizhen" uniqKey="Wu G" first="Guizhen" last="Wu">Guizhen Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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